Gabrie ten Have, one of CTRAL research scientists, has received an ESPEN Research Fellowship grant to study the effect of enteral nutritional intervention on glutathione metabolism during Pseudomonas aeruginosa sepsis.

The primary significance of this project is the development of a new approach to nutritional support in sepsis that will promote and preserve muscle mass and have no adverse physiological effects. 

Sepsis is also characterized by severe redox imbalance. Glutathione (GSH) plays a major role in cellular defense against oxidative and nitrosative stress. In septic patients, the GSH pool is depleted in muscle. Despite the well-recognized importance of supporting organ and tissue metabolism in sepsis with appropriate nutrition, there is little agreement on the best approach, probably also because we lack information on the effect on nutrition on GSH metabolism.

This research investigates the hypothesis that if nutritional therapy during sepsis is able to improve function and metabolism, also GSH synthesis is stimulated by increased availability of precursors.