The Center for Translational Research in Aging and Longevity hosted a seminar by Dr. Olav Rooijackers and Gabriella Ten Have on January 15, 2016. Olav Rooyackers is a Professor in Experimental Anesthesiology and Intensive Care at Karolinska Institutet in Sweden. His presentation is titled “Protein turnover and the effects of nutrition in critically ill patients.” Derangements in whole body and skeletal muscle protein turnover due to critical illness in patients treated in the ICU will be discussed in detail from tracer measurements till molecular changes.
The title of Gabriella Ten Have’s presentation is ” Whole body (Wb) Protein Synthesis (PS) and Breakdown (PB) in a Pseudomonas aeroginosa (PM) induced Hyper-dynamic Sepsis-recovery Pig Model during Enteral Intervention with Amino Acid (AA) mixtures”. Sepsis induces metabolic stress on multiple systems in the body. Muscle protein catabolism and altered gut protein metabolism contribute to mucosal atrophy and increased permeability. It is unclear how Wb PS and PB is affected during early enteral intervention with amino acid (AA) mixtures during an antibiotic induced sepsis recovery phase. Therefore, we measured Wb PS and PB in an acute live bacteria (PM) induced hyper-dynamic severe sepsis catheterized pig model during recovery.
A video of Dr. Rooijacker’s presentation is available here.